Renal recovery patterns and long-term kidney function decline in pulmonary hypertension

Abstract

Pulmonary hypertension (PH) is frequently accompanied by a decline in kidney function. In this retrospective cohort, worsening PH was associated with long-term eGFR decline only when accompanied by transition from acute kidney injury (AKI) to acute kidney disease (AKD), defined as persistent kidney dysfunction beyond 7 days after AKI onset, whereas early AKI reversal was not. These findings suggest that renal recovery patterns, rather than transient changes in kidney function, may determine longitudinal kidney outcomes in PH and warrant further prospective investigation.