The impact of granulocyte-macrophage colony-stimulating factor on lung epithelial cell injury and repair in severe influenza virus pneumonia

Kurzanzeige
dc.contributor.advisorHerold, Susanne
dc.contributor.authorSchäfer, Theresa M.
dc.date.accessioned2025-07-22T13:00:10Z
dc.date.available2025-07-22T13:00:10Z
dc.date.issued2025
dc.description.abstractGranulocyte-macrophage colony-stimulating factor (GM-CSF) exerts protective effects on bronchioalveolar stem cells (BASC) and alveolar epithelial cells type II (AECII) following viral lung injury by downregulating AMP-activated protein kinase (AMPK) signaling, which activates mechanistic target of rapamycin complex 1 (mTORC1). This activation supports the proliferation of epithelial stem cells and aids in the restoration of alveolar barrier function.
dc.description.sponsorshipSonstige Drittmittelgeber/-innen
dc.identifier.urihttps://jlupub.ub.uni-giessen.de/handle/jlupub/20725
dc.identifier.urihttps://doi.org/10.22029/jlupub-20075
dc.language.isoen
dc.rightsIn Copyright
dc.rights.urihttp://rightsstatements.org/page/InC/1.0/
dc.subjectlung research
dc.subjectinfectiology
dc.subjectacute lung injury
dc.subject.ddcddc:500
dc.subject.ddcddc:570
dc.subject.ddcddc:610
dc.titleThe impact of granulocyte-macrophage colony-stimulating factor on lung epithelial cell injury and repair in severe influenza virus pneumonia
dc.typedoctoralThesis
dcterms.dateAccepted2025-07-16
local.affiliationFB 11 - Medizin
thesis.levelthesis.doctoral

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