Pathomechanism of testicular inflammation in rat involves activation of proteinase activated receptor 2
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Mast cells are involved in early events crucial to inflammation and autoimmunedisease and their numbers increase in infertile testis. Recently, proteinaseactivated receptor-2 (PAR2), a G-protein coupled receptor important to injury responses, was shown to be activated by mast cell tryptase. To investigate whether mast cells and PAR2 are involved in the development and/oraggravation of testicular inflammation, we studied acute and chronicinflammatory models in the rat. Both testicular and systemic inflammatoryresponses can lead to impaired spermatogenesis, steroidogenesis and to maleinfertility. The rat experimental autoimmune orchitis (EAO) is thus far the beststudied model for immunological male factor infertility. In EAO, we detected asubstantial increase in the number of neutrophils, macrophages and mast cells,enlarged interstitial space, severe reduction and sloughing of the seminiferousepithelium and granuloma formation. Mast cells increased 10-fold in numbers,were more widely distributed and showed an increased degranulation rate.Verknüpfung zu Publikationen oder weiteren Datensätzen
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Giessen : VVB Laufersweiler 2006