Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart

dc.contributor.authorSchlüter, Klaus-Dieter
dc.contributor.authorSchulz, Rainer
dc.contributor.authorSchreckenberg, Rolf
dc.date.accessioned2022-11-18T09:50:50Z
dc.date.available2015-11-17T07:14:01Z
dc.date.available2022-11-18T09:50:50Z
dc.date.issued2015
dc.description.abstractInduction and activation of arginase is among the fastest responses of the heart to ischemic events. Induction of arginase expression and enzyme activation under ischemic conditions shifts arginine consumption from nitric oxide formation (NO) to the formation of ornithine and urea. In the heart such a switch in substrate utilization reduces the impact of the NO/cGMP-pathway on cardiac function that requires intact electromechanical coupling but at the same time it induces ornithine-dependent pathways such as the polyamine metabolism. Both effects significantly reduce the recovery of heart function during reperfusion and thereby limits the success of reperfusion strategies. In this context, changes in arginine consumption trigger cardiac remodeling in an unfavorable way and increases the risk of arrhythmia, specifically in the initial post-ischemic period in which arginase activity is dominating. However, during the entire ischemic period arginase activation might be a meaningful adaptation that is specifically relevant for reperfusion following prolonged ischemic periods. Therefore, a precise understanding about the underlying mechanism that leads to arginase induction as well as of it´s mechanistic impact on post-ischemic hearts is required for optimizing reperfusion strategies. In this review we will summarize our current understanding of these processes and give an outlook about possible treatment options for the future.en
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-117881
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/9143
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-8531
dc.language.isoende_DE
dc.rightsNamensnennung 3.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subjectornithineen
dc.subjectnitric oxideen
dc.subjectpolyaminesen
dc.subjectreactive oxygen speciesen
dc.subjectreperfusion injuryen
dc.subject.ddcddc:610de_DE
dc.titleArginase induction and activation during ischemia and reperfusion and functional consequences for the hearten
dc.typearticlede_DE
local.affiliationFB 11 - Medizinde_DE
local.opus.fachgebietMedizinde_DE
local.opus.id11788
local.opus.institutePhysiologisches Institutde_DE
local.source.freetextFrontiers in Physiology 6:65de_DE
local.source.urihttps://doi.org/10.3389/fphys.2015.00054

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