Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions
dc.contributor.author | Wernicke, Anna-Katharina | |
dc.contributor.author | Churin, Yuri | |
dc.contributor.author | Sheridan, Diana | |
dc.contributor.author | Windhorst, Anita | |
dc.contributor.author | Tschuschner, Annette | |
dc.contributor.author | Gattenlöhner, Stefan | |
dc.contributor.author | Roderfeld, Martin | |
dc.contributor.author | Roeb, Elke | |
dc.date.accessioned | 2022-11-18T09:52:16Z | |
dc.date.available | 2017-07-13T13:49:10Z | |
dc.date.available | 2022-11-18T09:52:16Z | |
dc.date.issued | 2016 | |
dc.description.abstract | An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. A reproducible staining procedure for histologic MMP-13 analysis in routinely fixed colorectal biopsy specimens has been established. A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout. The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-129827 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/9331 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-8719 | |
dc.language.iso | en | de_DE |
dc.rights | Namensnennung 3.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.subject | MMP | en |
dc.subject | neoplasia | en |
dc.subject | colon cancer | en |
dc.subject | adenoma | en |
dc.subject | immunoreactive scoring | en |
dc.subject.ddc | ddc:610 | de_DE |
dc.title | Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions | en |
dc.type | article | de_DE |
local.affiliation | FB 11 - Medizin | de_DE |
local.opus.fachgebiet | Medizin | de_DE |
local.opus.id | 12982 | |
local.opus.institute | Department of Gastroenterology | de_DE |
local.source.freetext | Oncotarget 7(45):73552-73557 | de_DE |
local.source.uri | https://doi.org/10.18632/oncotarget.12429 |
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