Apoptosis induction by Ochratoxin A, LPS, TNF-alpha, H2O2, and uv light in cultured primary rat hepatocytes, in immortalized rat liver cells and in human hepatoma cells and the prevention by Silibinin
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In this thesis, I showed that liver cell apoptosis by the mycotoxin ochratoxin Ain vitro is not mediated by cytokine TNF-alpha nor by direct binding to thereceptor TNFR1, but by oxygen radical formation that causes lipid peroxidationand was, thus, different from in vivo conditions in the intact rat liver. TNF-alpha produces apoptosis in liver cells via the extrinsic apoptosis pathway by usingTNFR1 and causes oxidative damage. However, OTA seems to cause apoptosisnot by activating the extrinsic pathway, but, rather the intrinsic pathway. Theherbal flavanolignan silibinin counteracted the cytotoxicity and induction ofapoptosis by OTA, TNF-alpha, H2O2, and UVC on primary rat hepatocytes culturesand thus was a potent cytoprotective and anti-apoptotic agent. Thisdistinguishes silibinin as a prophylactic hepatoprotective remedy.Verknüpfung zu Publikationen oder weiteren Datensätzen
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Giessen : VVB Laufersweiler