Expression and role of TASK-1 channels in pulmonary vessels and airways
Lade...
Datum
Autor:innen
Betreuer/Gutachter
Weitere Beteiligte
Beteiligte Institutionen
Herausgeber
Zeitschriftentitel
ISSN der Zeitschrift
Bandtitel
Verlag
Lizenz
Zitierlink
Zusammenfassung
TASK-1 is a member of the two pore domain K+ channel family. Its closing causes a decrease in K+ efflux, depolarization of cell membrane, opening of calcium channels and Ca2+ entry into the cell. This has been reported to occur under hypoxia while volatile anesthetics activate this channel. Consequently, TASK-1 may be involved in mechanisms of hypoxic pulmonary vasoconstriction (HPV) and anesthetics-induced inhibition of mucociliary clearance. In cell culture, the superoxide generating enzyme NOX4 has been considered as a functional partner of TASK-1 in O2 sensing. On this background, we set out to investigate in mice (1) the role of TASK-1 channel in HPV and bronchial constriction, (2) the functional relation between TASK-1 and NOX4 in sensing changes in O2 tension in pulmonary vessels, and (3) the role of TASK-1 in cilia driven particle transport on the tracheal mucosal surface.Verknüpfung zu Publikationen oder weiteren Datensätzen
Beschreibung
Anmerkungen
Erstpublikation in
Giessen : VVB Laufersweiler