Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-kappaB and Nrf2 in the duodenal mucosa of pigs
dc.contributor.author | Gessner, Denise | |
dc.contributor.author | Fiesel, Anja | |
dc.contributor.author | Most, Erika | |
dc.contributor.author | Dinges, Jennifer | |
dc.contributor.author | Wen, Gaiping | |
dc.contributor.author | Ringseis, Robert | |
dc.contributor.author | Eder, Klaus | |
dc.date.accessioned | 2022-11-18T09:50:22Z | |
dc.date.available | 2013-08-20T08:54:52Z | |
dc.date.available | 2022-11-18T09:50:22Z | |
dc.date.issued | 2013 | |
dc.description.abstract | BACKGROUND:In pigs, enteric infections and the development of gut disorders such as diarrhoea are commonly observed, particularly after weaning. The present study investigated the hypothesis that feeding a grape seed and grape marc extract (GSGME) as a dietary supplement has the potential to suppress the inflammatory process in the small intestine of pigs by modulating the activities of NF-kappaB and Nrf2 due to its high content of flavonoids. METHODS:Twenty-four crossbred, 6 weeks old pigs were randomly assigned to 2 groups of 12 animals each and fed nutritionally adequate diets without or with 1% GSGME for 4 weeks. RESULTS:Pigs administered GSGME had a lower transactivation of NF-kappaB and Nrf2 and a lower expression of various target genes of these transcription factors in the duodenal mucosa than control pigs (P<0.05). Concentrations of alpha-tocopherol and thiobarbituric acid reactive substances (TBARS) in liver and plasma and total antioxidant capacity of plasma and relative mRNA abundances of NF-kappaB and Nrf2 target genes in the liver did not differ between the two groups. However, the ratio of villus height:crypt depth and the gain:feed ratio was higher in the pigs fed GSGME than in control pigs (P<0.05). CONCLUSIONS:This study shows that dietary supplementation of a polyphenol rich GSGME suppresses the activity of NF-kappaB in the duodenal mucosa of pigs and thus might provide a useful dietary strategy to inhibit inflammation in the gut frequently occurring in pigs. Feeding GSGME did not influence vitamin E status and the antioxidant system of the pigs but improved the gain:feed ratio. In overall, the study suggests that polyphenol-rich plant extracts such GSGME could be useful feed supplements in pig nutrition, in order to maintain animal health and improve performance. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-100545 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/9023 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-8411 | |
dc.language.iso | en | de_DE |
dc.rights | Namensnennung 3.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
dc.subject | NF-kappaB | en |
dc.subject | Nrf2 | en |
dc.subject | olyphenol | en |
dc.subject | pig | en |
dc.subject | intestine | en |
dc.subject.ddc | ddc:630 | de_DE |
dc.title | Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-kappaB and Nrf2 in the duodenal mucosa of pigs | en |
dc.type | article | de_DE |
local.affiliation | FB 10 - Veterinärmedizin | de_DE |
local.opus.fachgebiet | Veterinärmedizin | de_DE |
local.opus.id | 10054 | |
local.source.freetext | Acta Veterinaria Scandinavica 55(1):18 | de_DE |
local.source.uri | https://doi.org/10.1186/1751-0147-55-18 |
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