Expression of estrogen receptors alpha and beta, aromatase, steroid sulfatase and estrogen sulfotransferase in testes of immature and mature boars
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Abstract
Estrogen action is mediated via estrogen receptor proteins (ERs). ERs occur in two forms, the classical ERalpha subtype and the novel ERbeta discovered in 1996. These proteins are also widely expressed in the male reproductive tract. Recent data from transgenic mice deficient in estrogen receptors or aromatase, points to an essential physiological role of estrogens for male fertility, which may, however, also be severely hampered by the administration of estrogens and xenoestrogens during fetal and neonatal development. These observations raise the question on the mechanisms of action of estrogens in the male.Together with the stallion the boar secretes remarkably high amounts of testicular estrogens. The present study was based on the hypothesis that these estrogens are likely to have local activity and hence designed to provide basic information on sources and targets of estrogens in the boar testis to set a foundation for further studies on their biological significance. In order to achieve this information, expression and localisation of the ERalpha and the ERbeta, cytochrome P450 aromatase, steroid sulfatase (StS) and estrogen sulfotransferase (EST) in the testes of immature and mature boars was assessed.Link to publications or other datasets
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Giessen : VVB Laufersweiler 2006