Dynamics of the human bile acid metabolome during weight loss

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dc.contributor.authorSchmid, Andreas
dc.contributor.authorLiebisch, Gerhard
dc.contributor.authorBurkhardt, Ralph
dc.contributor.authorBelikan, Hannah
dc.contributor.authorKöhler, Sebastian
dc.contributor.authorSteger, Daniel
dc.contributor.authorSchweitzer, Leonie
dc.contributor.authorPons-Kühnemann, Jörn
dc.contributor.authorKarrasch, Thomas
dc.contributor.authorSchäffler, Andreas
dc.date.accessioned2025-03-21T08:01:21Z
dc.date.available2025-03-21T08:01:21Z
dc.date.issued2024
dc.description.abstractBile acids (BA) are supposed to cause metabolic alterations after bariatric surgery (BS). Here we report the longitudinal dynamics of the human BA metabolome by LC–MS/MS after BS versus low calory diet (LCD) in two obesity cohorts over 12 months. Rapid and persistent oscillations of 23 BA subspecies could be identified with highly specific patterns in BS vs. LCD. TCDCA, GLCA, and TLCA represent most promising candidates for drug development.en
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG); ROR-ID:018mejw64
dc.identifier.urihttps://jlupub.ub.uni-giessen.de/handle/jlupub/20394
dc.identifier.urihttps://doi.org/10.22029/jlupub-19745
dc.language.isoen
dc.rightsNamensnennung 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddcddc:610
dc.titleDynamics of the human bile acid metabolome during weight loss
dc.typearticle
local.affiliationFB 11 - Medizin
local.projectHO 6929/2-1, SCHM 3261/3-1, KA 1846/4-1
local.source.articlenumber25743
local.source.epage11
local.source.journaltitleScientific reports
local.source.spage1
local.source.urihttps://doi.org/10.1038/s41598-024-75831-1
local.source.volume14

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