Einfluss inflammatorischer Stimuli auf das kardiomyozytäre Differenzierungspotential mesenchymaler Stammzellen

Abstract

The results of this project show that an inflammatory environment impairs the cardiac differentiation of stem cells. The meta-analyses show that stem cell therapies significantly reduce mortality and improve LVEF moderately, but significantly. However, the effect that was hoped for, namely the regeneration of infarcted tissue, does not materialize. The results of this study show that the inflammatory environment prevailing after a heart attack has a negative effect on the cardiac differentiation of stem cells. Modulation of the inflammatory niche could improve the cardiac differentiation rate of stem cells and thus achieve regeneration of the damaged myocardium. Further studies could focus on identifying factors that interfere with cardiac differentiation more precisely. Another starting point for research could be the modulation of inflammation, which would lead to better differentiation of the injected stem cells.