Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK
dc.contributor.author | Damm-Welk, Christine | |
dc.contributor.author | Siddiqi, Faraz | |
dc.contributor.author | Fischer, Matthias | |
dc.contributor.author | Hero, Barbara | |
dc.contributor.author | Narayanan, Vignesh | |
dc.contributor.author | Camidge, David Ross | |
dc.contributor.author | Harris, Michael | |
dc.contributor.author | Burke, Amos | |
dc.contributor.author | Lehrnbecher, Thomas | |
dc.contributor.author | Pulford, Karen | |
dc.contributor.author | Oschlies, Ilske | |
dc.contributor.author | Siebert, Reiner | |
dc.contributor.author | Turner, Suzanne | |
dc.contributor.author | Woessmann, Wilhelm | |
dc.date.accessioned | 2022-11-18T09:52:53Z | |
dc.date.available | 2018-11-27T14:00:37Z | |
dc.date.available | 2022-11-18T09:52:53Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Patients with Nucleophosmin (NPM)- Anaplastic Lymphoma Kinase (ALK) fusion positive Anaplastic Large Cell Lymphoma produce autoantibodies against ALK indicative of an immune response against epitopes of the chimeric fusion protein. We asked whether ALK-expression in other malignancies induces specific antibodies. Antibodies against ALK were detected in sera of one of 50 analysed ALK-expressing neuroblastoma patients, 13 of 21 ALK positive non-small cell lung carcinoma (NSCLC) patients, 13 of 22 ALK translocation-positive, but NPM-ALK-negative lymphoma patients and one of one ALK-positive rhabdomyosarcoma patient, but not in 20 healthy adults. These data suggest that boosting a pre-existent anti-ALK immune response may be more feasible for patients with ALK-positive NSCLC, lymphomas and rhabdomyosarcomas than for tumours expressing wild-type ALK. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-138808 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/9389 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-8777 | |
dc.language.iso | en | de_DE |
dc.rights | Namensnennung - Nicht-kommerziell 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | ALK-antibody titre | en |
dc.subject | NSCLC | en |
dc.subject | neuroblastoma | en |
dc.subject | lymphoma | en |
dc.subject.ddc | ddc:610 | de_DE |
dc.title | Anti-ALK Antibodies in Patients with ALK-Positive Malignancies Not Expressing NPM-ALK | en |
dc.type | article | de_DE |
local.affiliation | FB 11 - Medizin | de_DE |
local.opus.fachgebiet | Medizin | de_DE |
local.opus.id | 13880 | |
local.opus.institute | NHL-BFM Study Centre and Department of Paediatric Haematology and Oncology | de_DE |
local.source.freetext | Journal of Cancer 7(11):1383-1387 | de_DE |
local.source.uri | https://doi.org/10.7150/jca.15238 |
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