Activation of CD4+ and CD8+ T-lymphocytes by insulin and GAD in patients with type 1 or 2 diabetes mellitus
dc.contributor.author | Arneth, Borros | |
dc.date.accessioned | 2022-11-18T09:55:09Z | |
dc.date.available | 2020-08-05T07:27:30Z | |
dc.date.available | 2022-11-18T09:55:09Z | |
dc.date.issued | 2017 | |
dc.description.abstract | BACKGROUND: The origin of autoimmune disease type 1 diabetes is still unknown.AIM: This study assessed the activation of CD4+ and CD8+ T-lymphocytes by human insulin and human glutamate decarboxylase (GAD) in patients with type 1 or type 2 diabetes mellitus (DM) and healthy volunteers.MATERIALS AND METHODS: The expression of CD69, a marker of T-lymphocyte activity, was determined in whole blood samples by flow cytometry after 12 h of incubation with or without insulin or GAD. The analysis included samples from 12 type 1 DM patients, 14 type 2 DM patients and 12 healthy volunteers.RESULTS: Significant increases in the number of activated CD4+ and CD8+ T-lymphocytes following pre-incubation of whole blood samples with human insulin or GAD were observed in samples from patients with type 1 DM, whereas no activation of these cells was detected in samples from either type 2 DM patients or healthy subjects.DISCUSSION: These results indicated that latent pre-activation of CD4+ and CD8+ T-lymphocytes in response to insulin or GAD epitopes occurred in type 1 DM patients.CONCLUSION: These findings suggest that pre-immunization against insulin and/or GAD might be associated with the development of type 1 DM. Alternatively, these results might reflect a non-specific, bystander autoimmune response. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-153712 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/9557 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-8945 | |
dc.language.iso | en | de_DE |
dc.rights | Namensnennung 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.ddc | ddc:610 | de_DE |
dc.title | Activation of CD4+ and CD8+ T-lymphocytes by insulin and GAD in patients with type 1 or 2 diabetes mellitus | en |
dc.type | article | de_DE |
local.affiliation | FB 11 - Medizin | de_DE |
local.opus.fachgebiet | Medizin | de_DE |
local.opus.id | 15371 | |
local.opus.institute | Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics | de_DE |
local.source.freetext | Endocrine Connections 6(8):758-765 | de_DE |
local.source.uri | https://doi.org/10.1530/EC-17-0230 |
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