Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes

dc.contributor.authorBanning, Antje
dc.contributor.authorOckenga, Wymke
dc.contributor.authorFinger, Fabian
dc.contributor.authorSiebrasse, Philipp
dc.contributor.authorTikkanen, Ritva
dc.date.accessioned2022-11-18T09:56:53Z
dc.date.available2012-11-20T14:15:20Z
dc.date.available2022-11-18T09:56:53Z
dc.date.issued2012
dc.description.abstractFlotillin-1 and flotillin-2 are important regulators of signal transduction pathways such as growth factor signaling. Flotillin expression is increased under pathological conditions such as neurodegenerative disorders and cancer. Despite their importance for signal transduction, very little is known about the transcriptional regulation of flotillins. Here, we analyzed the expression of flotillins at transcriptional level and identified flotillins as downstream targets of the mitogen activated kinases ERK1/2. The promoter activity of flotillins was increased upon growth factor stimulation in a MAPK dependent manner. Overexpression of serum response factor or early growth response gene 1 resulted in increased flotillin mRNA and protein expression. Furthermore, both promoter activity and expression of endogenous flotillins were increased upon treatment with retinoic acid or by overexpression of the retinoid X receptor and its binding partners RARa and PPAR?. Our data indicate that the expression of flotillins, which can be detected in all cultured cells, is fine-tuned in response to various external stimuli. This regulation may be critical for the outcome of signaling cascades in which flotillins are known to be involved.en
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-90719
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/9660
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-9048
dc.language.isoende_DE
dc.rightsNamensnennung 3.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subjectflotillinsen
dc.subjecttranscriptional regulationen
dc.subjectERK1/2en
dc.subjectretinoic aciden
dc.subjectretinoid X receptoren
dc.subject.ddcddc:610de_DE
dc.titleTranscriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexesen
dc.typearticlede_DE
local.affiliationFB 11 - Medizinde_DE
local.opus.fachgebietMedizinde_DE
local.opus.id9071
local.opus.instituteInstitute of Biochemistryde_DE
local.source.freetextPLoS ONE, 7(9), e45514, 1-17de_DE
local.source.urihttps://doi.org/10.1371/journal.pone.0045514

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