BAG3: An enticing therapeutic target for idiopathic pulmonary fibrosis
dc.contributor.author | Chillappagari, Shashipavan | |
dc.contributor.author | Guenther, Andreas | |
dc.contributor.author | Mahavadi, Poornima | |
dc.date.accessioned | 2023-12-05T11:26:19Z | |
dc.date.available | 2023-12-05T11:26:19Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Idiopathic pulmonary fibrosis (IPF) is a dreadful and fatal disease of unknown etiology, for which no cure exists. Autophagy, a lysosomal cellular surveillance pathway is insufficiently activated in both alveolar epithelial type II cells and fibroblasts of IPF patient lungs. Fine-tuning this pathway may result in the degradation of the accumulated cargo and influence cell fate. Based on our previous data, we here present our view on modulating autophagy via a unique co-chaperone, namely Bcl2-associated athanogene3 (BAG3) in IPF and discuss about how repurposing drugs that modulate this pathway may emerge as a promising novel therapeutic approach for IPF. | |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft (DFG); ROR-ID:018mejw64 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/18744 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-18108 | |
dc.language.iso | en | |
dc.rights | Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | autophagy | |
dc.subject | BAG3 | |
dc.subject | idiopathic pulmonary fibrosis | |
dc.subject | therapeutic intervention | |
dc.subject.ddc | ddc:610 | |
dc.title | BAG3: An enticing therapeutic target for idiopathic pulmonary fibrosis | |
dc.type | article | |
local.affiliation | FB 11 - Medizin | |
local.project | MA 6621/2 | |
local.source.journaltitle | Journal of cellular biochemistry | |
local.source.uri | https://doi.org/10.1002/jcb.30446 | |
local.source.volume | 127 |
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