High-sensitivity cardiac troponin T and copeptin assays to improve diagnostic accuracy of exercise stress test in patients with suspected coronary artery disease
dc.contributor.author | Liebetrau, Christoph | |
dc.contributor.author | Gaede, Luise | |
dc.contributor.author | Dörr, Oliver | |
dc.contributor.author | Hoffmann, Jedrzej | |
dc.contributor.author | Wolter, Jan S. | |
dc.contributor.author | Weber, Michael | |
dc.contributor.author | Rolf, Andreas | |
dc.contributor.author | Hamm, Christian W. | |
dc.contributor.author | Nef, Holger M. | |
dc.contributor.author | Möllmann, Helge | |
dc.date.accessioned | 2023-06-02T13:37:36Z | |
dc.date.available | 2017-01-25T12:44:52Z | |
dc.date.available | 2023-06-02T13:37:36Z | |
dc.date.issued | 2015 | |
dc.description.abstract | Background: The average diagnostic sensitivity of exercise stress tests (ESTs) is lower than that of other non-invasive cardiac stress tests. The aim of the study was to examine whether high-sensitivity cardiac troponin T (hs-cTnT) or copeptin concentrations rise in response to inducible myocardial ischaemia and may improve the diagnostic accuracy of ESTs.Methods and results: An EST was performed stepwise on a bicycle ergometer by 383 consecutive patients with suspected or progression of coronary artery disease (CAD). In addition venous blood samples for measurement of hs-cTnT and copeptin were collected prior to EST, at peak exercise, and 4 h after EST. Coronary angiography was assessed for all patients. Patients with significant CAD (n=224) were more likely to be male and older compared to patients with non-significant CAD (n=169). Positive EST was documented in 125 (55.8%) patients with significant CAD and in 69 (43.4%) patients with non-significant CAD. Copeptin and hs-cTnT concentrations at baseline were higher in patients with significant CAD (copeptin: 10.8 pmol/l (interquartile range (IQR) 8.1 15.6) vs 9.4 pmol/l (IQR 7.1 13.9); p=0.04; hs-cTnT: 3.0 ng/l (IQR <3.0 5.4) vs <3.0 ng/l (IQR <3.0); p=0.006). Hs-cTnT improved sensitivity (61.6% vs 55.8%), specificity (67.7% vs 56.6%) and the positive predictive value (PPV) (72.3% vs 64.4%) and negative (55.2% vs 47.6%) predictive value (NPV) of EST. Copeptin could not improve sensitivity (55.4% vs 55.8%) and reduced specificity, PPV and NPV.Conclusions: The measurement of hs-cTnT during EST improves sensitivity, specificity, and positive and negative predictive values. In contrast, measurement of copeptin does not improve diagnostic sensitivity and reduces specificity. | en |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-124568 | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/16361 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-15741 | |
dc.language.iso | en | de_DE |
dc.rights | In Copyright | * |
dc.rights.uri | http://rightsstatements.org/page/InC/1.0/ | * |
dc.subject | coronary artery disease | en |
dc.subject | cardiac troponin T | en |
dc.subject | copeptin | en |
dc.subject | exercise stress test | en |
dc.subject | myocardial ischaemia | en |
dc.subject.ddc | ddc:610 | de_DE |
dc.title | High-sensitivity cardiac troponin T and copeptin assays to improve diagnostic accuracy of exercise stress test in patients with suspected coronary artery disease | en |
dc.type | article | de_DE |
local.affiliation | FB 11 - Medizin | de_DE |
local.comment | Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. | |
local.opus.fachgebiet | Medizin | de_DE |
local.opus.id | 12456 | |
local.opus.institute | Division of Cardiology | de_DE |
local.source.freetext | European Journal of Preventive Cardiology 22(6): 684 692; DOI: 10.1177/2047487314529691 | de_DE |
local.source.uri | https://doi.org/10.1177/2047487314529691 |
Dateien
Originalbündel
1 - 1 von 1