Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study
dc.contributor.author | Sammer, Gebhard | |
dc.contributor.author | Neumann, Elena | |
dc.contributor.author | Blecker, Carlo | |
dc.contributor.author | Pedraz-Petrozzi, Bruno | |
dc.date.accessioned | 2023-04-13T12:39:38Z | |
dc.date.available | 2023-04-13T12:39:38Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Over the past few years, evidence of a positive relationship between inflammation and depression has grown steadily. The aim of the current study was to investigate whether such depression-related inflammation could also be associated with altered microstructural changes in the white matter. FA and serum cytokines (IL-1β, IL-6, TNF-α, and IFN-γ) were measured in 25 patients with depression (DE) and 24 healthy controls (HC). Diffusion tensor imaging was performed. Fractional anisotropy (FA) was calculated using the FSL pipeline for Tract-Based Spatial Statistics (TBSS). Both voxelwise and mean whole-brain FA were analyzed using general linear models (GLM). Higher concentrations of IL-1β were associated with lower whole-brain fractional anisotropy, particularly in people with depression (ρ = − 0.67; p < 0.001). TNF-α shared some variance with IL-1β and also showed a negative relationship between TNF-α concentrations and FA in depression ( F1,46 = 11.13, p = 0.002, η2p = 0.21). In detail, the voxelwise analysis showed that the regression slopes of IL-1β on FA were more negative in the DE group than in the HC group, mainly in the corpus callosum (cluster statistics: genu corpus callosum, p = 0.022; splenium of corpus callosum, p = 0.047). Similar effects were not found for the other remaining cytokines. This study clearly demonstrated an association between peripherally measured IL-1β and white matter integrity in depression as assessed by DTI. The results suggest that microstructural changes in the corpus callosum are associated with increased peripheral IL-1β concentrations in depression. | |
dc.identifier.uri | https://jlupub.ub.uni-giessen.de//handle/jlupub/16211 | |
dc.identifier.uri | http://dx.doi.org/10.22029/jlupub-15593 | |
dc.language.iso | en | |
dc.rights | Namensnennung 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.ddc | ddc:610 | |
dc.title | Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study | |
dc.type | article | |
local.affiliation | FB 11 - Medizin | |
local.source.articlenumber | 17450 | |
local.source.epage | 10 | |
local.source.journaltitle | Scientific reports | |
local.source.spage | 1 | |
local.source.uri | https://doi.org/10.1038/s41598-022-22437-0 | |
local.source.volume | 12 |
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