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dc.contributor.authorBayat, Behnaz
dc.contributor.authorLowack, Jonas
dc.contributor.authorAudrain, Marie
dc.contributor.authorCroisille, Laure
dc.contributor.authorCurtis, Brian
dc.contributor.authorDangerfield, Rebecca
dc.contributor.authorEsmaeili, Behnaz
dc.contributor.authorGrabowski, Claudia
dc.contributor.authorKeller, Margaret
dc.contributor.authorKim, Hyungsuk
dc.contributor.authorKroll, Hartmut
dc.contributor.authorKvanka, Marjeta Macek
dc.contributor.authorKwok, Janette
dc.contributor.authorMoritz, Elyse
dc.contributor.authorNathalang, Oytip
dc.contributor.authorNelson, Derrick
dc.contributor.authorNielsen, Kaspar René
dc.contributor.authorPahn, Gail
dc.contributor.authorPoles, Anthony
dc.contributor.authorPorcelijn, Leendert
dc.contributor.authorSachs, Ulrich J.
dc.contributor.authorSchönbacher, Marlies
dc.contributor.authorKörmöczi, Günther F.
dc.contributor.authorKupatawintu, Pawinee
dc.contributor.authorTakahashi, Daisuke
dc.contributor.authorUhrynowska, Malgorzata
dc.contributor.authorFlesch, Brigitte
dc.contributor.authorFung, Yoke-Lin
dc.date.accessioned2023-11-22T12:39:27Z
dc.date.available2023-11-22T12:39:27Z
dc.date.issued2023
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/18694
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-18058
dc.description.abstractBackground and Objectives: Human neutrophil antigens (HNAs) are categorized into five systems: HNA-1 to HNA-5. Given the importance of neutrophils in immunity, we sought to create awareness of the role of HNA diagnostic services in managing immune neutropenia and transfusion-related acute lung injury. To provide health communities all around the world with access to these services, we conducted a survey to create a directory of these HNA diagnostic services. Materials and Methods: An Excel table-based survey was created to capture information on the laboratory’s location and was emailed to 55 individuals with known or possible HNA investigation activity. The collected data were then summarized and analysed. Results: Of contacted laboratories, the surveys were returned from 23 (38.2%) laboratories; 17 have already established HNA diagnostic (of them 12 were regular participants of the International Granulocyte Immunobiology Workshop [ISBT-IGIW]), 4 laboratories were in the process of establishing their HNA investigation and the remaining 2 responder laboratories, did not conduct HNA investigations. In established laboratories, investigation for autoimmune neutropenia (infancies and adults) was the most frequently requested, and antibodies against HNA-1a and HNA-1b were the most commonly detected. Conclusion: The directory of survey respondents provides a resource for health professionals wanting to access HNA diagnostic services. The present study offers a comprehensive picture of HNA diagnostics (typing and serology), identifying weak points and areas for improvement for the first time. Identifying more laboratories involved in HNA diagnostics with limited access to international societies in the field will globally improve HNA diagnostics.
dc.language.isoen
dc.rightsNamensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectalloantibody
dc.subjectautoantibody
dc.subjectautoimmune
dc.subjectHNA
dc.subjectneutropenia
dc.subjectneutrophil
dc.subjectTRALI
dc.subject.ddcddc:610
dc.titleWorld human neutrophil antigens investigation survey
dc.typearticle
local.affiliationFB 11 - Medizin
local.source.spage763
local.source.epage774
local.source.journaltitleVox sanguinis
local.source.volume118
local.source.number9
local.source.urihttps://doi.org/10.1111/vox.13500


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