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dc.contributor.authorChong, Lei
dc.contributor.authorAhmadvand, Negah
dc.contributor.authorNoori, Afshin
dc.contributor.authorLv, Yuqing
dc.contributor.authorChen, Chengshui
dc.contributor.authorBellusci, Saverio
dc.contributor.authorZhang, Jin-San
dc.date.accessioned2024-02-07T14:24:17Z
dc.date.available2024-02-07T14:24:17Z
dc.date.issued2023
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/18990
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-18351
dc.description.abstractAlveolar epithelial type II cells (AT2s) together with AT1s constitute the epithelial lining of lung alveoli. In contrast to the large flat AT1s, AT2s are cuboidal and smaller. In addition to surfactant production, AT2s also serve as prime alveolar progenitors in homeostasis and play an important role during regeneration/repair. Based on different lineage tracing strategies in mice and single-cell transcriptomic analysis, recent reports highlight the heterogeneous nature of AT2s. These studies present compelling evidence for the presence of stable or transitory AT2 subpopulations with distinct marker expression, signaling pathway activation and functional properties. Despite demonstrated progenitor potentials of AT2s in maintaining homeostasis, through self-renewal and differentiation to AT1s, the exact identity, full progenitor potential and regulation of these progenitor cells, especially in the context of human diseases remain unclear. We recently identified a novel subset of AT2 progenitors named “Injury-Activated Alveolar Progenitors” (IAAPs), which express low levels of Sftpc, Sftpb, Sftpa1, Fgfr2b and Etv5, but are highly enriched for the expression of the surface receptor programmed cell death-ligand 1 (Pd-l1). IAAPs are quiescent during lung homeostasis but activated upon injury with the potential to proliferate and differentiate into AT2s. Significantly, a similar population of PD-L1 positive cells expressing intermediate levels of SFTPC are found to be expanded in human IPF lungs. We summarize here the current understanding of this newly discovered AT2 progenitor subpopulation and also try to reconcile the relationship between different AT2 stem cell subpopulations regarding their progenitor potential, regulation, and relevance to disease pathogenesis and therapeutic interventions.de_DE
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG); ROR-ID:018mejw64de_DE
dc.language.isoende_DE
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.ddcddc:610de_DE
dc.titleInjury activated alveolar progenitors (IAAPs): the underdog of lung repairde_DE
dc.typearticlede_DE
local.affiliationFB 11 - Medizinde_DE
local.projectBE4443/18-1, BE4443/1-1, BE4443/4-1, BE4443/6-1, KFO309 284237345 P7 and SFB CRC1213 268555672 projects A02 and A04de_DE
local.source.journaltitleCellular and molecular life sciencesde_DE
local.source.volume80de_DE
local.source.articlenumber145de_DE
local.source.urihttps://doi.org/10.1007/s00018-023-04789-6de_DE


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