Covalently trapping MutS on DNA to study DNA mismatch recognition and signaling

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dc.contributor.authorHeinze, Roger J.
dc.contributor.authorSekerina, Svetlana
dc.contributor.authorWinkler, Ines
dc.contributor.authorBiertuempfel, Christian
dc.contributor.authorOretskaya, Tatiana S.
dc.contributor.authorKubareva, Elena
dc.contributor.authorFriedhoff, Peter
dc.date.accessioned2023-06-02T13:37:44Z
dc.date.available2013-07-11T07:14:35Z
dc.date.available2023-06-02T13:37:44Z
dc.date.issued2012
dc.description.abstractThe DNA repair protein MutS forms clamp-like structures on DNA that search for and recognize base mismatches leading to ATP-transformed signaling clamps. In this study, the mobile MutS clamps were trapped on DNA in a functional state using single-cysteine variants of MutS and thiol-modified homoduplex or heteroduplex DNA. This approach allows stabilization of various transient MutS-DNA complexes and will enable their structural and functional analysis.en
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:hebis:26-opus-98851
dc.identifier.urihttps://jlupub.ub.uni-giessen.de//handle/jlupub/16399
dc.identifier.urihttp://dx.doi.org/10.22029/jlupub-15779
dc.language.isoende_DE
dc.rightsIn Copyright*
dc.rights.urihttp://rightsstatements.org/page/InC/1.0/*
dc.subject.ddcddc:570de_DE
dc.titleCovalently trapping MutS on DNA to study DNA mismatch recognition and signalingen
dc.typearticlede_DE
local.affiliationFB 08 - Biologie und Chemiede_DE
local.commentDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
local.opus.fachgebietBiologiede_DE
local.opus.id9885
local.opus.instituteInstitute for Biochemistryde_DE
local.source.freetextMolecular BioSystems 8(7):1861-1864 doi: 10.1039/c2mb25086ade_DE
local.source.urihttps://doi.org/10.1039/c2mb25086a

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