Molecular mediators of alveolarization
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Abstract
Egr1 is a growth factor with multiple different interaction partners and numerous effectscovering most of the known cellular processes. Having found a postnatal downregulationof this anti-proliferative, pro-apoptotic molecule fits the needs of highdivision ratios within alveolarization, but may also depict a diminished necessity ofdifferentiation. Stainings revealed single alveolar septal cells of both models to (over-)express Egr1, potentially emphasizing a local pro-proliferative influence of the growthfactor within this lung region.The pneumonectomy model, showing an up-regulation of Egr1, probably involves theMAPK signalling pathway, as some additional members of this regulatory chain werefound to be overexpressed as well. In consequence, not only Egr1, but also thesecandidates should be further studied in order to find targets for potential tissueregrowth. In a first step, lungs of Egr1-knockout or -overexpressing mice may bestereologically quantified to curtail the degree of influence the growth factor has onboth models presented here.Link to publications or other datasets
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Giessen : VVB Laufersweiler